Trifluoromethyl-pyrazole-carboxamides as COX inhibitors: synthesis, microed structural analysis, computational profiling, and biological evaluation.

ABSTRACT:

Background

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed medications for the treatment of inflammation, pain, and fever, primarily acting as competitive inhibitors of the cyclooxygenase (COX) enzymes.

Objectives

The present study aimed to design a series of trifluoromethyl-pyrazole-carboxamide derivatives as potential NSAID candidates, with a focus on achieving selective COX-2 inhibition and reduced cytotoxicity. In addition, their potential anticancer effects and pharmacokinetic properties were evaluated through in vitro and in silico analyses.

Methods

The coupling reaction of aniline derivatives and pyrazole-carboxylic acid was used to synthesize a series of trifluoromethyl-pyrazole-carboxamide derivatives. Initially, the newly

SUBMITTER: Hawash M 

PROVIDER: S-EPMC12573903 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature