IgD in nucleus of pro-B cells promotes pro-B cells proliferation by regulating E2F3 expression.

ABSTRACT:

Background

Immunoglobulin D (IgD) has historically been considered as a surface marker of mature B cell with its specific function being undefined. Until now, no evidence had been presented to suggest that IgD is also expressed in pro-B cells. This study was designed to elucidate the significance for IgD in early B cell development.

Results

Here we developed a mouse model with a targeted deletion of IgD, and assessed the production of the IgM, IgG and IgA, as well as the generation of the antigen specific antibodies. The findings indicated no significant differences in these Ig levels between wild-type and IgD-deficient mice. However, we observed a notable reduction in the number of mature B cells, which led us to the surprising discovery that this decrease in B cell count b

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12573911 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature