Insulin resistance surrogates predict major adverse cardiovascular events in patients with heart failure with preserved ejection fraction and chronic kidney disease: a retrospective cohort study.

ABSTRACT:

Background

Heart failure with preserved ejection fraction (HFpEF) and chronic kidney disease (CKD) frequently coexist and portend a poor prognosis. Insulin resistance (IR) is implicated in cardiorenal pathophysiology, but practical surrogate IR indices for predicting risk in this high-risk and understudied population are lacking. This study evaluated and compared the prognostic value of four IR indices for major adverse cardiovascular events (MACE) in patients with HFpEF and CKD, and assessed their incremental value over the established Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) risk score.

Methods

This retrospective analysis included 2412 patients admitted with HFpEF and CKD from 2012 to 2023. Baseline metabolic parameters computed four IR indices: triglyc

SUBMITTER: Wang F 

PROVIDER: S-EPMC12573933 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature