Sex differences in Alzheimer's disease CSF biomarkers and their association with Aβ pathology on PET in cognitively unimpaired individuals.

ABSTRACT:

Background

Alzheimer's disease (AD) exhibits sex differences in prevalence, symptoms and risk factors. Understanding the effect of sex in AD cerebrospinal fluid (CSF) biomarkers and their association with amyloid-beta (Aβ) pathology in preclinical stages have important implications for their use in prevention trials. The objective of this study was to examine sex differences in core AD CSF biomarkers used in early diagnosis and prevention trials, as well as in CSF biomarkers reflecting downstream pathophysiological mechanisms, and in their associations with Aβ pathology as measured by Positron Emission Tomography (PET).

Methods

Cognitively Unimpaired (CU) participants from the ALFA + (N = 400) and the WRAP/WADRC (N = 548) cohorts were included in the study. CSF biomarkers fo

SUBMITTER: Mila-Aloma M 

PROVIDER: S-EPMC12573942 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature