The association of plasma testosterone level and progression of diabetic nephropathy in male.

ABSTRACT:

Background

Diabetic nephropathy (DN) is a leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD), significantly impacting the global burden of diabetes mellitus (DM). Testosterone has been implicated in the pathophysiology of DN, yet its specific role remains unclear.

Methods

This retrospective cohort study analyzed 347 male patients with type 2 diabetes mellitus (T2DM), including 165 with DN and 182 without DN, to explore the relationship between plasma testosterone levels and DN progression. Clinical and biochemical data were collected, and univariate, multivariate regression, and logistic regression analyses were performed. A nomogram predictive model was developed incorporating DN risk factors.

Results

No significant difference in plasma

SUBMITTER: Tang K 

PROVIDER: S-EPMC12573948 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature