Immunogenicity and safety of polio vaccines in infants: a systematic review of randomized clinical trials.

ABSTRACT: Poliomyelitis, preventable only through vaccination, remains a global health concern, with wild poliovirus transmission and the emergence of vaccine-derived polioviruses. The risk of further deterioration of the situation jeopardizes efforts to eradicate polio, which has been a long-term goal for the whole world. In this systematic review, an analysis of randomized clinical trials was carried out to comprehensively assess the immunogenicity and safety of various polio immunization methods in infants. Geometric mean neutralizing antibody titers (GMT) data collected after 28-31 days after immunization were used to calculate the geometric mean titer ratio (GMR), the analysis of which showed that both inactivated polio vaccine (IPV) and Sabin strain-based inactivated polio vaccine (sIPV) as pr

SUBMITTER: Terekhov RP 

PROVIDER: S-EPMC12573955 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature