Immune, blood-brain barrier, and metabolic biomarkers mediate gut-brain axis crosstalk in alzheimer's disease.

ABSTRACT:

Background

Gut microbiota may influence Alzheimer's disease (AD) pathogenesis by modulating host homeostasis. However, population-based causal evidence linking gut dysbiosis to Alzheimer's disease pathogenesis, especially via immune, vascular, and metabolic pathways, remains insufficient.

Methods

We performed Mendelian randomization (MR) and colocalization analysis on 629 gut microbiota features and 2,103 immune, blood-brain barrier (BBB), and metabolic biomarkers regarding the risk of AD and cerebrospinal fluid (CSF) pathological biomarkers.

Results

We identified that mucin-degraders, short-chain fatty acid (SCFA) producers, and Programmed Cell Death Protein 1/Programmed Death-Ligand 1 (PD-1/PD-L1)-related biomarkers were associated with lower AD risk, while cardiova

SUBMITTER: Li J 

PROVIDER: S-EPMC12573957 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature