Central obesity measured by waist-to-hip ratio independently predicts crohn's disease risk: a prospective cohort study.

ABSTRACT:

Objective

This study evaluated associations between several obesity indicators and the risks of Crohn's disease (CD) and ulcerative colitis (UC), the two principal clinical phenotypes of inflammatory bowel disease (IBD).

Methods

Data from 479,590 UK Biobank participants (mean age ± standard deviation: 56.5 ± 8.09 years; 54.5% female) were analyzed. Participants were classified based on waist circumference (WC). Cox proportional hazards models were used to quantify associations between multiple adiposity measures and incident CD and UC, adjusting for demographic, behavioral, and clinical covariates.

Results

During a median observation period of 12.5 years (maximum 15.6 years), 1,518 incident CD cases and 2,957 incident UC cases were identified. Taking into account demo

SUBMITTER: Sun L 

PROVIDER: S-EPMC12573991 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature