Maternal-to-neonatal microbial transmission and impact of prenatal probiotics on neonatal gut development.

ABSTRACT:

Background

Maternal microbiota during pregnancy plays a crucial role in establishing the neonatal gut microbiota, which is essential for infant health. This study aimed to trace maternal microbial sources contributing to early neonatal gut colonization and assess the effect of prenatal probiotic supplementation on maternal-to-neonatal microbial transmission.

Methods

A total of 26 mother-neonate pairs undergoing full-term vaginal delivery were enrolled. From gestational week 32 until delivery, the intervention group received a probiotic supplement containing Bifidobacterium longum, Lactobacillus delbrueckii bulgaricus, and Streptococcus thermophilus twice daily, while the control group received no supplementation. Maternal fecal, vaginal, and placental samples were collected

SUBMITTER: Meng L 

PROVIDER: S-EPMC12573995 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature