Albumin-corrected anion gap and risk of mortality among US adults.

ABSTRACT:

Background

Elevated albumin-corrected anion gap (ACAG) has been linked to increased mortality across various patient populations, but its prognostic value in the general population remains unclear. This study examined the association between ACAG and all-cause, cardiovascular disease (CVD), and cancer mortality among US adults.

Methods

Data from 40,702 adults aged ≥ 20 years were analyzed from the National Health and Nutrition Examination Survey 1999-2018. ACAG was calculated as: anion gap + (4.4 - serum albumin [g/dL]) × 2.5. Cox proportional hazards models, restricted cubic splines, and Kaplan-Meier curves were used to assess associations. Subgroup and sensitivity analyses were conducted.

Results

Over a median 113 month follow-up, 6,087 deaths occurred, including 1,

SUBMITTER: Ni ZB 

PROVIDER: S-EPMC12574005 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature