The mediation of circulating inflammatory proteins in the causal pathway from immune cells to osteoarthritis.

ABSTRACT:

Background

Observational studies have found that immune cells and circulating inflammatory proteins play a dual role in the progression of osteoarthritis, but the exact mechanism remains unclear. Therefore, this study aimed to investigate whether the causal relationship between immune cells and Knee OA is mediated by circulating inflammatory proteins.

Method

A two-sample Mendelian Randomization analysis was conducted involving 731 immune cells, 91 inflammatory proteins and OA, utilising summary-level data from genome-wide association studies. The causal relationships between immune cells, inflammatory proteins and OA were sequentially analysed by multivariate Mendelian Randomization and validated using Bayesian weighted Mendelian Randomization. Subsequently, sensitivity anal

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC12574021 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature