Recent intake of direct oral anticoagulants and acute ischemic stroke: real world data from a comprehensive stroke center.

ABSTRACT:

Background

Deciding on intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) patients with reported recent direct oral anticoagulant (DOAC) intake remains challenging due to concerns about hemorrhagic risk and the absence of randomized controlled trial evidence. This study aimed to provide a comprehensive characterization of all AIS patients with reported recent DOAC intake-regardless of IVT eligibility-treated at a comprehensive stroke center that routinely measures calibrated anti-facor IIa/Xa activity at admission.

Methods

In this retrospective study, clinical and procedural data from AIS patients with recent DOAC intake and calibrated anti-factor IIa/Xa activity measured within three hours of admission were analyzed. Patients were treated at the University Hospit

SUBMITTER: Pommeranz D 

PROVIDER: S-EPMC12574025 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature