Mesenchymal stem cell derived extracellular vesicles reverses neural aging via OSKM modulation.

ABSTRACT:

Background

Intravenously infused human placenta-derived mesenchymal stem cells enhance overall function and exhibit therapeutic potential even with minimal engraftment or tissue replacement, with substances released from human placenta-derived mesenchymal stem cells playing a significant role in these positive outcomes. Stem cell-derived extracellular vesicles transfer beneficial factors that aid recovery in various tissues through genetic regulation. However, the effects of systemically injected mesenchymal stem cells and their released derivatives on normal aging have not been reported.

Methods

Aged female mice received intravenous infusions of human placenta-derived mesenchymal stem cells. Starting at 18-19 months of age, mice were given injections of either human placent

SUBMITTER: Kim C 

PROVIDER: S-EPMC12574049 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature