Transcranial and precise optical neuromodulation mediated by NIR photoactive nanosheets.

ABSTRACT: Remote modulation of specific neurons is critical for neural circuit dissection and neurological disease therapy. Traditional neuromodulation strategies applying electrodes and external stimuli may suffer from invasive injuries and insufficient spatiotemporal resolution, respectively. Herein, transcranial optical neuromodulation with precise spatiotemporal control was realized by establishing a nanophotonic neural interface, where the polyethylene glycol-modified two-dimensional Ti₃C₂T_x (MXene) served as near-infrared (NIR) photoactive nanosheets (PANS). Polymer modification of the nanosheets contributed to a robust PANS-neuron interface, which allowed efficient modulation of non-transgenic neurons with subcellular resolution and millisecond precision. The

SUBMITTER: Yang D 

PROVIDER: S-EPMC12574063 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature