Inositol supplementation efficacy in improving key cardiometabolic and anthropometric indices: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Inositol and its derivatives may help mitigate risks associated with cardiovascular diseases; however, existing evidence remains inconsistent.

Objectives

The primary aim of this systematic review and meta-analysis of RCTs was to quantify the effects of inositol and its stereoisomers on anthropometric, and cardiometabolic measures.

Methods

A systematic review and meta-analysis of RCTs was conducted to clarify this. Searches in PubMed and Scopus, along with hand-searching references, identified RCTs on inositol supplementation lasting ≥ 4-week. Using random-effects models, the analysis determined mean effect sizes as weighted mean differences (WMD) with 95% CIs. Heterogeneity was assessed via the Cochrane Chi-squared test and Galbraith plots, while the ROBI t

SUBMITTER: Delavar MA 

PROVIDER: S-EPMC12574088 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature