Abnormal structural gray matter and structural covariance networks associated with biopsychosocial characteristics in children with multisite pain.

ABSTRACT:

Background

Overwhelming evidence suggests that adults with chronic pain have altered brain structure and related networks. However, little is currently known regarding changes in structural gray matter and structural covariance networks (SCNs) in children with multisite pain (MP) and their potential relationships with biopsychosocial characteristics.

Methods

This study enrolled 444 children with MP and 444 matched controls from the Adolescent Brain Cognitive Development Study. All participants underwent magnetic resonance imaging (MRI) scans following biopsychosocial assessment. Then, SCNs matrices were constructed by the Brain Connectivity Toolbox based on both cortical thickness (CT) and cortical surface area (CSA) among 415 children with MP and 404 controls. Nonparametric

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC12574090 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature