Neural mechanisms of suicide thoughts and behaviors in major depressive disorder: abnormal regional brain activity and its functional connectivity.

ABSTRACT:

Background

Suicide thoughts and behaviors (STB), including suicidal ideation (SI) and suicide attempts (SA), are significant concerns in major depressive disorder (MDD), yet their neurobiological mechanisms remain poorly understood. This study aims to identify key regional brain activity and connectivity abnormalities associated with STB in MDD by combining a meta-analysis of regional brain activity comparing MDD patients with STB to non-STB controls (both MDD without STB and healthy controls) and an exploratory functional connectivity (FC) analysis in an independent sample of MDD patients.

Methods

A meta-analysis employing Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) software identified regional brain abnormalities. Studies included were those comparing

SUBMITTER: Jing Y 

PROVIDER: S-EPMC12574107 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature