The chaperone GrpE mediates adhesion in Mycoplasma bovis and interactions with host extracellular matrix components and plasminogen.

ABSTRACT: Mycoplasma bovis (M. bovis) is a significant pathogen responsible for various clinical manifestations in cattle, including pneumonia, mastitis, and arthritis. The challenges associated with managing M. bovis infections include the absence of specific therapeutic agents, increasing antibiotic resistance and the absence of an effective commercial vaccine. The chaperone GrpE is a crucial component of mycoplasma bacteria. However, because there are few tools for genetic manipulation of M. bovis, the role of GrpE in pathogenicity is yet unknown. In this study, GrpE was universally present in the tested M. bovis strains, and it was localized on the surface membrane. We first demonstrated that GrpE plays a vital role in the ability of M. bovis to adhere to embryonic bovine lung (EBL) cells in a d

SUBMITTER: Jin X 

PROVIDER: S-EPMC12574120 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature