KLOTHO-VS heterozygosity, α-klotho protein levels and cognitive performance in Alzheimer's disease.

ABSTRACT:

Background

KLOTHO-VS (KL-VS) heterozygosity, a variant of the KLOTHO gene, and its encoded protein, α-Klotho, are associated with brain health and show neuroprotective potential against Alzheimer's disease (AD). We aimed to assess whether KL-VS heterozygosity, cerebrospinal fluid (CSF) and serum soluble α-Klotho (sαKl) levels, would be associated with a lower likelihood of AD and better performance on memory and other cognitive domains in individuals with AD dementia, amnestic mild cognitive impairment (aMCI) due to AD, and cognitively unimpaired controls.

Methods

In this cross-sectional study, we analyzed two partially overlapping subsamples derived from 296 participants from the Czech Brain Aging Study. The first subsample included 196 participants with KL-VS haplotype dat

SUBMITTER: Katonova A 

PROVIDER: S-EPMC12574126 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature