Taurodeoxycholic, taurocholic, and glycocholic acids promote hepatic gluconeogenesis via TGR5 in dairy cows.

ABSTRACT:

Background

Ruminants and monogastric animals exhibit significant differences in gluconeogenic efficiency. In dairy cows, hepatic gluconeogenesis serves as the primary source of glucose. Metabolites modulate gluconeogenesis efficiency through allosteric regulation, redox state, and signal transduction pathways. However, the liver-enriched metabolites that regulate hepatic gluconeogenesis in dairy cows and their specific regulatory mechanisms remain incompletely characterized.

Results

Six Holstein dairy cows and six Duroc × (Landrace × Yorkshire) (DLY) crossbred pigs served as research subjects. Employing non-targeted and targeted metabolomics, we discovered that three bile acids-taurodeoxycholic acid (TDCA), taurocholic acid (TCA), and glycocholic acid (GCA)-were highly enric

SUBMITTER: Zhu M 

PROVIDER: S-EPMC12574133 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature