Dataset Information
Predicting the methylation status of CpG islands from read distribution biases.
Ontology highlight
ABSTRACT:
SUBMITTER: Abdullaev ET
PROVIDER: S-EPMC12574136 | biostudies-literature | 2025 Oct
REPOSITORIES: biostudies-literature
Publications
Predicting the methylation status of CpG islands from read distribution biases.
BMC genomics 20251030 1
DNA methylation is an important epigenetic mark that plays a major role in transcriptional regulation, development and genome integrity. There are state-of-the-art methods, such as whole-genome bisulfite sequencing or long-read sequencing, which allow accurate detection of DNA methylation at single-base resolution. However, except for these specialized methods, information about DNA methylation status cannot be obtained directly from ordinary short-read sequencing data. Here we propose an approa ...[more]
