Yiqi Wenyang Formula ameliorates diabetic kidney disease via inhibiting inflammation and regulating the gut microbiota-bile acid axis in mice by FXR signaling pathway.

ABSTRACT:

Background

Diabetic kidney disease (DKD) is a microangiopathic complication of diabetes. Yiqi Wenyang Formula (YQWYF) has been used to treat DKD in the clinic for many years. However, the underlying regulatory mechanisms of YQWYF on the gut microbiota and bile acids of DKD mice remain unclear.

Purpose of the research

This study aimed to investigate the mechanism of YQWYF on DKD mice using an integrative approach of network pharmacology, fecal 16S ribosomal RNA (rRNA) gene sequencing, and untargeted metabolomics.

Methods

The chemical composition of YQWYF was determined via ultrahigh-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). Common targets were identified between YQWYF and DKD, and a potential protein-protein interact

SUBMITTER: Yuan T 

PROVIDER: S-EPMC12574177 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature