Neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) mediates the relationship between abdominal fat index and depression in a cross-sectional study.

ABSTRACT:

Objective

Investigate the link between abdominal adipose tissue index and depression, and assess the mediating effect of the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) in this association.

Methods

Participants were chosen using datasets from the National Health and Nutrition Examination Survey (NHANES). To assess the associations between abdominal adipose tissue index and depression, a weighted logistic regression analysis was conducted. Adjusted logistic regression models and restricted cubic splines were used to examine the relationship between subcutaneous and visceral adipose tissue index and depression, with subgroup analyses conducted according to demographic characteristics, personal habits, and comorbidities. The mediation model assessed the poten

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12574252 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature