Gut microbiota-derived short-chain fatty acids promote follicular maturation via gWAT-ovary axis in mammals.

ABSTRACT:

Background

Previous studies have demonstrated that gut microbiota regulates reproductive performance in mammals. Our prior research identified the gut microbiota-ovary axis as an important contributor to the superior follicular development observed in Chinese indigenous Meishan sows, yet the underlying mechanisms remain unclear. This study aims to elucidate the mechanism through which gut microbiota regulates follicular development.

Results

Fecal microbiota transplantation (FMT) from Meishan sows promoted follicular maturation in recipient Landrace × Yorkshire sows, evidenced by increased numbers of antral follicles, secondary follicles, and corpora lutea, accompanied by decreased atretic follicles. Additionally, FMT altered reproductive hormone profiles, significantly eleva

SUBMITTER: Xu B 

PROVIDER: S-EPMC12574281 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature