Interleukin 10 enhances endothelial progenitor cell-mediated angiogenesis in extrahepatic portal venous obstruction.

ABSTRACT:

Objectives

In this study, the therapeutic potential of endothelial progenitor cells (EPCs) in restoring portal vein blood flow in a rat model of extrahepatic portal venous obstruction (EHPVO) was investigated, and the underlying mechanisms were explored.

Methods

Rats were divided into normal control (NC), EHPVO, EPC, knockout control-EPC (KO-NC-EPC), and knockout IL-10-EPC (KO-IL-10-EPC) groups. Portal blood flow was measured using a flowmeter. The numbers of blood capillaries and changes in portal vein diameter were analyzed using HE staining. RT-qPCR, Western blotting, and ELISA were employed to assess the relative cytokine levels in portal venous blood and liver tissues.

Results

Compared with the NC group, the EHPVO group exhibited significantly reduced portal bloo

SUBMITTER: Zhang JS 

PROVIDER: S-EPMC12574303 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature