Prognosis in stage II colorectal cancer: the effect of the primary tumor location and biomarkers-a retrospective cohort study.

ABSTRACT:

Background

The prognostic impact of primary tumor location (right- vs left-sided) is well-established in stage III/IV colorectal cancer (CRC), with right-sided tumors associated with poorer outcomes. However, its prognostic role in stage II CRC remains unclear. This study investigates whether the worse outcomes observed in advanced right-sided cancers also apply to early-stage CRC, or if they may be influenced by other factors such as patient demographics and molecular biomarkers. Clarifying this could help improve risk stratification in clinical practice.

Methodology

For this study, we analyzed data of all Belgian patients diagnosed with stage II CRC in 2015-2016 (n = 3.278, data obtained from the Belgian Cancer Registry). Information on primary tumor location, demographics

SUBMITTER: Colebunders J 

PROVIDER: S-EPMC12574333 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature