Identifying modifiable factors and their joint associations on late-onset schizophrenia risk in the UK Biobank: a prospective exposure-wide association study.

ABSTRACT:

Background

One in four cases of schizophrenia begins in late life, resulting in high unemployment and reduced life expectancy. However, knowledge of the modifiable risk factors for late-onset schizophrenia and their combined effects is limited.

Aims

To identify modifiable risk factors for late-onset schizophrenia and estimate their joint disease risk effects.

Methods

This prospective cohort study using UK Biobank data included 482 708 participants without late-onset schizophrenia at baseline, followed up for a mean of 14.36 years. We conducted an exposure-wide association study of 232 potentially modifiable factors linked to late-onset schizophrenia risk. Late-onset schizophrenia is diagnosed using ICD-10 (International Classification of Diseases, 10th Revision) crite

SUBMITTER: Jiang F 

PROVIDER: S-EPMC12574375 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature