Genetic Variation in the Alternative Complement Pathway Contributes to Individual Susceptibility to Bacteremia and Sepsis.

ABSTRACT:

Importance

The alternative complement pathway is a key component of host defense against bacteremia and other infections. However, dysregulated activation can contribute to excessive inflammation and worse clinical outcomes during bacteremia and infectious syndromes such as sepsis.

Objectives

We aim to identify variants in alternative pathway (AP) genes that influence the risk for bacteremia and sepsis.

Design, setting, and participants

We used summary statistics from a Veterans Affairs Million Veteran Program (MVP) genome-wide by phenome-wide association study of more than 600,000 individuals.

Main outcomes and measures

Using seven electronic health record-derived Phecodes for bacteremia or sepsis, we investigated associations with single-nucleotide polymorphi

SUBMITTER: Inman K 

PROVIDER: S-EPMC12574529 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature