Integrative DNA methylation and transcriptome analysis reveal cell-type specific patterns in response to elevated allostatic load.

ABSTRACT: Allostatic load (AL) is a measure of the body's multi-systemic physiological dysregulation in response to chronic stress and life events. High AL has been associated with poor long-term health outcomes such as cardiovascular disease and mortality. DNA methylation (DNAm) is an epigenetic mechanism involving both genes and environmental factors and contributes to gene expression regulation. Hence, changes in AL can possibly be reflected in DNAm and gene expression differences and leveraging epigenetic and transcriptomic data together can help elucidate the underlying biological processes involved. To assess differential DNAm and gene expression between high and low AL in a cell-type specific manner, bulk DNAm and transcriptome signals from whole blood samples of 429 individuals from the Swis

SUBMITTER: Emery O 

PROVIDER: S-EPMC12574575 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature