Neutrophil extracellular trap-borne C3-driven endothelial dysfunction in <i>Klebsiella pneumoniae</i> liver abscess.

ABSTRACT: Klebsiella pneumoniae (K. pneumoniae) liver abscess (KPLA) is a severe bacterial infection that is frequently complicated by intrahepatic thrombophlebitis and extrahepatic metastatic infections leading to high mortality rates. This study investigates the role of neutrophil extracellular traps (NETs) in endothelial injury and disease progression in KPLA. Our findings reveal that KPLA patients with intrahepatic thrombophlebitis are more prone to developing sepsis and extrahepatic migratory infections. K. pneumoniae induces NET formation via the TLR4-PI3Kα-AKT signaling pathway, and C3 deposition on NETs significantly contributes to endothelial injury. In a KPLA mouse model, increased C3 levels were observed in the liver, with NETs carrying substantial amounts of C3, disr

SUBMITTER: Wang H 

PROVIDER: S-EPMC12574580 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature