Retrospective study: the value of GDF-15 and conventional markers in combination for clinical diagnosis of lung cancer.

ABSTRACT: Lung cancer is a leading cause of morbidity and mortality worldwide, and effective biomarkers for its screening and monitoring are still lacking. This study aims to assess the diagnostic value of Growth Differentiation Factor 15 (GDF15) in lung cancer and its subtypes, compared to conventional biomarkers, to evaluate its potential as a predictive biomarker for lung cancer screening and monitoring. GDF15 levels were measured and analyzed in different subtypes of lung cancer and non-tumor controls. The correlation between GDF15 and the expression of eight conventional biomarkers was assessed by analyzing serum GDF15 levels in the markers^normal groups and the markers^high groups. The superiority of GDF15 in screening and monitoring of lung cancer was confirmed using the r

SUBMITTER: Ni J 

PROVIDER: S-EPMC12574585 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature