Differential hypothalamic regulation of FSH and LH secretion from the fish pituitary by GnRH and CCK.

ABSTRACT:

In brief

The hypothalamus-pituitary-gonad axis integrates environmental and internal signals to tune reproductive functions. We hypothesized that in fish, Gnrh predominantly stimulates luteinizing hormone (LH) secretion, while Cck selectively regulates follicle-stimulating hormone (FSH), thereby uncovering a novel role for Cck as a metabolic gatekeeper that links reproductive activity with nutritional status.

Abstract

In fish, the hypothalamus-pituitary-gonad axis governs reproduction in response to environmental and internal signals. FSH regulates gonadal growth, while LH controls maturation. Gonadotropin-releasing hormone (Gnrh) plays a key role in this process, while the role of the satiety hormone cholecystokinin (Cck) is under investigation. We hypothesized that Gnrh an

SUBMITTER: Mizrahi N 

PROVIDER: S-EPMC12574605 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature