G-quadruplex ligand RHPS4 compromises cellular radioresistance by inhibiting the mitochondrial adaptive response induced by ionizing irradiation.

ABSTRACT: A major challenge in radiotherapy is to enhance tumour cell sensitivity to radiation while minimizing damage to healthy tissues. Enhancing the effectiveness of radiotherapy can be achieved by combining irradiation with small radiosensitizing molecules, which promote cancer cell death and allow for reduced radiation doses, thereby limiting harm to surrounding healthy tissues. Since mitochondria play a key role in tumour cell proliferation, they represent a promising therapeutic target for cancer treatment. In this study, we characterized the impact of irradiation on mitochondrial function in radioresistant cancer cells. Our findings revealed several adaptive responses that may contribute to radioresistance, including increased mitochondrial DNA (mtDNA) content, mitochondrial mass, enhanced

SUBMITTER: Tricot S 

PROVIDER: S-EPMC12574668 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature