Accessible, Realistic Genome Simulation with Selection Using stdpopsim.

ABSTRACT: Selection is a fundamental evolutionary force that shapes patterns of genetic variation across species. However, simulations incorporating realistic selection along heterogeneous genomes in complex demographic histories are challenging, limiting our ability to benchmark statistical methods aimed at detecting selection and to explore theoretical predictions. stdpopsim is a community-maintained simulation library that already provides an extensive catalog of species-specific population genetic models. Here, we present a major extension to the stdpopsim framework that enables simulation of various modes of selection, including background selection, selective sweeps, and arbitrary distributions of fitness effects (DFE) acting on annotated subsets of the genome (for instance, exons). This exten

SUBMITTER: Gower G 

PROVIDER: S-EPMC12574676 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature