Nrf2 Deficiency in Muller Cells Exacerbates Pathological Neovascularization in Ischemic Retinopathy.

ABSTRACT:

Background

Müller cells are the major retinal glial cell type and pivotal regulators of pathological neovascularization in ischemic retinopathy. There is great interest in identifying factors that govern Müller cells in vascular regulation. Nrf2 (NF-E2-related factor 2) plays a major protective role in regulating oxidative stress and inflammation. Our group previously discovered that both global and neuroretinal Nrf2 deficiency suppress retinal revascularization and promote pathological neovascularization in a mouse model of oxygen-induced retinopathy. Here, we investigate the cell-intrinsic role of Nrf2 in Müller cells on retinal angiogenesis.

Methods

The role of Müller cell Nrf2 in retinal angiogenesis was investigated in cell culture and the mouse oxygen-induced retinopat

SUBMITTER: Xu Z 

PROVIDER: S-EPMC12574687 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature