M6A RNA methylation regulator-associated genes drive metastasis and immune cell infiltration in skin cutaneous melanoma.

ABSTRACT: Skin cutaneous melanoma (SKCM) is a highly aggressive malignancy, and understanding the mechanisms underlying its metastasis is essential for improving patient prognosis. N6-methyladenosine (m6A) RNA modification is involved in tumor progression; however, its specific role in SKCM metastasis remains poorly defined. The present study aimed to identify m6A-related regulatory genes associated with SKCM metastasis and to assess their impact on the tumor immune microenvironment. Expression data from primary and metastatic SKCM samples were obtained from the Gene Expression Omnibus (GSE8401, GSE15605, GSE46517 and GSE65904) and The Cancer Genome Atlas-SKCM databases. A metastasis-risk prediction model was constructed using least absolute shrinkage and selection operator-Cox regression analysis.

SUBMITTER: Geng Y 

PROVIDER: S-EPMC12574698 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature