Identification of EFNA3 as candidate prognosis marker and potential therapeutic target for adrenocortical carcinoma.

ABSTRACT: Adrenocortical carcinoma (ACC) is a rare, but highly aggressive endocrine malignancy with poor prognosis and limited treatment options. Identifying novel biomarkers and therapeutic targets is essential for improving patient outcomes. The present study aimed to systematically characterize ephrin-A3 (EFNA3) expression patterns, its prognostic and diagnostic value, and its functional role in ACC progression through multi-omics bioinformatics and in vitro validation. Transcriptomic, epigenetic and pharmacogenomic data were obtained from The Cancer Genome Atlas, Genotype-Tissue Expression, Genomics of Drug Sensitivity in Cancer, Cancer Therapeutics Response Portal and MethSurv databases. Expression, survival, immune infiltration, methylation and drug sensitivity analyses were conducted u

SUBMITTER: Tai Y 

PROVIDER: S-EPMC12574699 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature