Understanding How Low Luminance Visual Deficit Progresses With Advancing Diabetic Macular Ischemia and Diabetic Retinopathy.

ABSTRACT:

Purpose

To assess whether low luminance deficit (LLD) correlates with diabetic macular ischemia on optical coherence tomography angiography (OCTA).

Methods

Best-corrected visual acuity (BCVA) and low luminance visual acuity (LLVA; using 2.0-log unit neutral density filter) were assessed with Early Treatment Diabetic Retinopathy Study (ETDRS) charts and recorded as ETDRS letter scores. Low-luminance deficit (LLD) was calculated as BCVA - LLVA. From OCTA 3 × 3 mm scans, geometric perfusion deficits (GPD), vessel length density (VLD), and vessel density (VD) in deep (DCP) and superficial (SCP) capillary plexuses were quantified. Linear regression analyzed associations between LLD and OCTA metrics.

Results

The study included 91 non-referable (no/mild DR), 94 referable (mo

SUBMITTER: Shah J 

PROVIDER: S-EPMC12574731 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature