Helicobacter pylori Infection's Dual Impact on the Ocular Surface: Tear Secretion Disruption and Ocular Surface Microbiome Alteration.

ABSTRACT:

Purpose

The purpose of this study was to investigate the impact of Helicobacter pylori (H. pylori) infection on ocular surface homeostasis, including dry eye symptoms, ocular microbiota alterations, and related immune responses.

Methods

Thirty-one H. pylori-positive (Hp_pos) and 30 H. pylori-negative (Hp_neg) subjects underwent dry eye assessments, including the Schirmer I test, noninvasive keratography first and average breakup times (NIKf-BUTs and NIKav-BUTs), tear meniscus height, meibomian gland loss, and the Ocular Surface Disease Index (OSDI). Sterile swabs were used to collect samples from each eye of subjects for 16S rRNA sequencing. Additionally, a murine H. pylori infection model was established to evaluate dry eye phenotypes and immune responses in the lacrimal gl

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12574735 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature