NT-proBNP testing for heart failure diagnosis in people with atrial fibrillation: A diagnostic accuracy study.

ABSTRACT:

Background

N-terminal pro-B-type natriuretic peptides (NT-proBNP) are important in the assessment of suspected heart failure (HF). However, NT-proBNP concentrations are elevated in atrial fibrillation (AF), creating diagnostic uncertainty. The aim of this study was to assess the diagnostic accuracy of NT-proBNP for HF in people with AF, overall and by age, sex and BMI.

Methods and findings

Retrospective study of all patients with a NT-proBNP test in their primary care electronic health record among English GP practices provided through the Clinical Practice Research Datalink (2004-2018) and linked to secondary care data. The accuracy of NT-proBNP for diagnosing HF within six months was assessed for people with and without AF at thresholds of 125, 400, 660 and 2,000 pg/mL, in

SUBMITTER: Jones NR 

PROVIDER: S-EPMC12574882 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature