Identification of natural Zika virus peptides presented on the surface of paediatric brain tumour cells by HLA class I.

ABSTRACT: Despite decades of research, survival from brain cancer has scarcely improved and is drastically lower than that of other cancers. Novel therapies, such as immunotherapy, hold great promise for treating brain tumours and are desperately needed. Zika virus (ZIKV) infects and kills aggressive cancer cells with stem-like properties (CSCs) from both paediatric and adult brain tumours. Whilst T cell recruitment into ZIKV-infected brain tumours is becoming well documented, the specific mechanisms through which they are activated are poorly understood. We address this by employing a combined global proteome and immunopeptidome mass spectrometry approach to describe, for the first time, human leukocyte antigen (HLA) presentation of ZIKV peptides on the surface of infected brain tumour cells. We fi

SUBMITTER: Sherwood M 

PROVIDER: S-EPMC12574884 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature