Persistent Subclinical Inflammation and Long-term Functional and Cognitive Outcomes After Dengue Shock and Septic Shock in Vietnam.

ABSTRACT:

Background

There have been no studies reporting functional, cognitive, inflammatory or endothelial outcomes after dengue shock (DS), or septic shock (SS) in Vietnam.

Methods

We conducted a prospective observational study to follow-up adult survivors of DS and SS. At hospital discharge, 1-, 3-, and 6-month follow-up, we measured health-related quality of life (EQ-5D-5L), cognitive function (Montreal Cognitive Assessment, MoCA), endothelial function (EndoPAT), and plasma biomarkers of inflammation (ferritin, IL-6, CRP) and endothelial activation (Ang1, Ang2, VCAM-1).

Results

Participants included survivors of DS (n = 130), SS (n = 26), and healthy controls (n = 25). Survivors of DS had median EQ-5D-5L visual analogue score (VAS) > 90/100 at all time-points, and mildly i

SUBMITTER: McBride A 

PROVIDER: S-EPMC12575078 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature