The Increased Risk for Postinfluenza Pneumonia Among Cystic Fibrosis Carriers-A Population-Based Study.

ABSTRACT:

Background

Influenza is strongly associated with an increased risk for subsequent bacterial pneumonia. Moreover, cystic fibrosis (CF) carriers are at increased risk for some pulmonary infections. The purpose of this study was to determine whether CF carriers are at greater risk for postinfluenza pneumonia than noncarriers.

Methods

Using MarketScan insurance claims data (2001-2023), we identified a study cohort of 38 047 CF carriers and a cohort of 380 470 matched controls. We conducted 2 analyses using these cohorts. First, we assessed individual-level risk for experiencing pneumonia following an influenza infection. Second, because many cases of influenza often do not result in medical visits, we conducted a cohort-level analysis comparing the weekly incidence of pneumonia

SUBMITTER: Miller AC 

PROVIDER: S-EPMC12575080 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature