Condition-dependent resource allocation strategy governed by CodY regulator in <i>Bacillus subtilis</i>.

ABSTRACT: To thrive in nature, bacteria have to rapidly proliferate in favorable conditions while constantly adapt to the fluctuating nutrient environments. However, the molecular players that ensure rapid growth of bacteria in favorable conditions remain poorly understood. Here, we focus on the growth physiology of Bacillus subtilis and find that codY knockout strongly compromises cell growth in rich medium. Global proteome allocation analysis has shown that codY knockout causes a "waste" of cellular resources by stimulating unnecessary expression of many proteins, further reducing the cellular investment on translation machinery. Therefore, CodY-dependent repression is crucial in ensuring rapid growth of B. subtilis in rich medium. On the other hand, the relief of CodY-

SUBMITTER: Mu H 

PROVIDER: S-EPMC12575088 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature