Risk factors of osteonecrosis in patients with systemic lupus erythematosus: a meta-analysis.

ABSTRACT:

Background

This study aimed to explore risk factors for osteonecrosis in patients with systemic lupus erythematosus by meta-analysis.

Methods

PubMed, Embase, Web of Science, and Cochrane Library were searched for case-control/cohort studies on the occurrence of osteonecrosis in patients with systemic lupus erythematosus from the time the database was created until 1 December 2024. Data were analyzed using Stata 15.0, and the quality of the included studies was evaluated using the NOS score.

Result

A total of 14 articles, including 3,890 patients, were included in the study, and the meta-analysis indicates that younger age in SLE patients [SMD = -0.23, 95% CI (-0.39, -0.06)], diabetes mellitus [OR = 1.78, 95% CI (1.03, 3.09)], hypertension [OR = 1.33, 95% CI (1.03, 1.7

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12575097 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature