Metabolic score for insulin resistance and the incidence of cardiovascular disease: a meta-analysis of cohort studies.

ABSTRACT: Cardiovascular disease (CVD) remains the leading global cause of mortality, with insulin resistance as a pivotal metabolic risk factor that promotes endothelial dysfunction, inflammation, and atherosclerosis via mechanisms such as impaired nitric oxide signaling and enhanced oxidative stress. The metabolic score for insulin resistance (METS-IR), a non-insulin-based index derived from fasting blood glucose, triglycerides, high-density lipoprotein cholesterol, and body mass index, offers a practical surrogate for assessing insulin sensitivity. However, its association with incident CVD has not been systematically evaluated in a meta-analysis. This meta-analysis aimed to quantify the relationship between baseline METS-IR and the incidence of composite CVD, coronary artery disease (CAD), and s

SUBMITTER: He Y 

PROVIDER: S-EPMC12575141 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature