Boron neutron capture therapy in the context of tumor heterogeneity: progress, challenges, and future perspectives.

ABSTRACT: Boron neutron capture therapy (BNCT), as an emerging binary treatment method, has shown the advantage of effectively treating tumors while sparing normal tissues, utilizing the characteristics of boron's nuclear capture and fission reactions, as well as the distinct distribution of boron delivery agents in tumor tissues and healthy tissues. Currently, numerous boron delivery agents have been developed to improve their targeting property, biocompatibility, solubility, and nuclear localization capability. The shift of neutron source from being based on nuclear reactors to being based on accelerators facilitates the conduct of clinical trials. BNCT has demonstrated promising results in treating head and neck cancers, gliomas, and skin melanomas. In addition, researches on the application of B

SUBMITTER: Zhou R 

PROVIDER: S-EPMC12575145 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature