Therapeutic potential of <i>Glycyrrhiza</i> polysaccharides in pseudorabies virus infection: immune modulation, antioxidant activity, and gut microbiota restoration.

ABSTRACT:

Aim of the study

This study aimed to evaluate the protective effects of Glycyrrhiza polysaccharides (GPs) on Pseudorabies virus (PRV)-infected mice and elucidate their mechanisms of action, with a focus on intestinal immunity, oxidative stress, mucosal barrier function, and gut microbiota composition.

Materials and methods

GPs were extracted via hot water extraction and ethanol precipitation. Seventy-two SPF-grade male mice were randomly divided into six groups and treated with different doses of GPs or Astragalus polysaccharides (APS), followed by PRV challenge. Clinical parameters, inflammatory cytokines (TNF-α, IL-6, IL-4, IL-10), oxidative stress markers (SOD, CAT, MDA), histopathology, tight junction protein expression (Occludin, ZO-1), sIgA levels,

SUBMITTER: Song C 

PROVIDER: S-EPMC12575151 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature