The inflammatory architecture reflects the effects of pharmacological and genetic interventions on resolution of TLR2-mediated inflammation.

ABSTRACT:

Introduction

Immune cells form defined pro- and anti-inflammatory regions around a pathogen during an innate immune response. These include, in Toll-like receptor (TLR)-2-induced inflammation, a core region containing the pathogen, an adjacent pro-inflammatory (PI) region and a surrounding anti-inflammatory (AI) region. Interventions targeting specific immune cells or signaling pathways disrupt this architecture and affect the resolution of inflammation. Here, we investigated, which changes in the inflammatory architecture may favor an increased resolution of inflammation.

Methods

Immune cell networks and defined inflammatory regions were detected by high content imaging in an inflammation model induced by the TLR2 agonist zymosan. Resolution of inflammation was determined u

SUBMITTER: Kramer C 

PROVIDER: S-EPMC12575189 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature