Sulfotransferase SULT2B1 contributes to the epithelial-immune microenvironment homeostasis in imiquimod-induced psoriatic dermatitis.

ABSTRACT:

Introduction

Skin protects the body from external threats by constituting an epithelial-immune microenvironment. Sulfotransferase family 2B member 1 (SULT2B1) converts cholesterol to cholesterol sulfate (CS). We previously reported that CS acts as an endogenous dedicator of cytokinesis 2 (DOCK2)-inhibitory metabolite suppressing immune cell migration and activation by inhibiting DOCK2-mediated Rac activation. Despite being located in the epidermis, pathophysiological roles of CS in cutaneous inflammation remain unknown.

Methods

We evaluated the Sult2b1-producing cells in the dorsal skin of wild-type mice and compared the degree of cutaneous inflammation between wild-type and Sult2b1 knockout mice using a psoriatic dermatitis model induced by topical imiquimod (

SUBMITTER: Morino K 

PROVIDER: S-EPMC12575227 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature